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產(chǎn)品規(guī)格
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BN41180R-100ul
100ul
￥2360.00
交叉反應：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Horse) 推薦應用：IHC-P,IHC-F,IF,ELISA
BN41180R-200ul
200ul
￥3490.00
交叉反應：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Horse) 推薦應用：IHC-P,IHC-F,IF,ELISA
產(chǎn)品描述
| 英文名稱 | KLHL7 |
| 中文名稱 | kelch樣蛋白7抗體 |
| 別 名 | Kelch like protein 7; kelch-like 6; kelch-like 7; kelch/BTB.KLHL7_HUMAN |
| 研究領域 | 腫瘤 免疫學 染色質(zhì)和核信號 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Mouse, Rat, (predicted: Human, Chicken, Dog, Pig, Cow, Horse, ) |
| 產(chǎn)品應用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 64kDa |
| 細胞定位 | 細胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KLHL7:51-150/856 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | This gene encodes a BTB-Kelch-related protein. The encoded protein may be involved in protein degradation. Mutations in this gene have been associated with retinitis pigmentosa 42. [provided by RefSeq, Feb 2010]. Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination. Subunit: Homodimer. Component of the BCR(KLHL7) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL7 and RBX1. Subcellular Location: Nucleus. Tissue Specificity: Widely expressed, with highest levels in adult and fetal heart, CNS and adult testis. DISEASE: Defects in KLHL7 are the cause of retinitis pigmentosa type 42 (RP42) [MIM:612943]. A retinal dystrophy belonging to the group of pigmentary retinopathies. RP is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Similarity: Contains 1 BACK (BTB/Kelch associated) domain. Contains 1 BTB (POZ) domain. Contains 6 Kelch repeats. SWISS: Q8IXQ5 Gene ID: 55975 Database links: Entrez Gene: 55975 Human Entrez Gene: 52323 Mouse Omim: 611119 Human SwissProt: Q8IXQ5 Human SwissProt: Q8BUL5 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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