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產(chǎn)品規(guī)格
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BN41244R-100ul
100ul
￥2360.00
交叉反應：Human,Rat(predicted:Mouse,Chicken,Pig,Cow) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN41244R-200ul
200ul
￥3490.00
交叉反應：Human,Rat(predicted:Mouse,Chicken,Pig,Cow) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
產(chǎn)品描述
| 英文名稱 | DEDD1 |
| 中文名稱 | 死亡效應結(jié)構域蛋白1抗體 |
| 別 名 | CASP8IP1; Death effector domain containing; Death effector domain containing protein; Death effector domain containing testicular molecule; DEDD 1; DEDD1; DEDPro 1; DEDPro1; DEFT; FLDED 1; FLDED1; KE 05; KE05; OTTHUMP00000031822. |
| 研究領域 | 腫瘤 細胞生物 細胞凋亡 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, Rat, (predicted: Mouse, Chicken, Pig, Cow, ) |
| 產(chǎn)品應用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 35kDa |
| 細胞定位 | 細胞核 細胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DEDD1:151-250/318 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. Function: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro. Subunit: Interacts with CASP8, CASP10, KRT8, KRT18, CASP3 and FADD. Homodimerizes and heterodimerizes with DEDD2. Subcellular Location: Cytoplasm. Nucleus, nucleolus. Tissue Specificity: Widely expressed with highest levels in testis. Post-translational modifications: Exists predominantly in a mono- or diubiquitinated form. Similarity: Contains 1 DED (death effector) domain. SWISS: O75618 Gene ID: 9191 Database links: Entrez Gene: 9191 Human Entrez Gene: 21945 Mouse Omim: 606841 Human SwissProt: O75618 Human SwissProt: Q9Z1L3 Mouse Unigene: 146406 Human Unigene: 270139 Mouse Unigene: 203286 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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