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BN41470R-50ul
50ul
￥1486.00
交叉反應(yīng)：Rat,Mouse,Human(predicted:Pig,Dog) 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41470R-100ul
100ul
￥2360.00
交叉反應(yīng)：Rat,Mouse,Human(predicted:Pig,Dog) 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41470R-200ul
200ul
￥3490.00
交叉反應(yīng)：Rat,Mouse,Human(predicted:Pig,Dog) 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA
產(chǎn)品描述
| 英文名稱 | ChAT |
| 中文名稱 | ChAT膽堿乙酰轉(zhuǎn)移酶抗體 |
| 別 名 | Choline O acetyltransferase; Choline O acetyltransferase; Acetyl CoA choline O acetyltransferase; Acetyl CoA:choline O acetyltransferase; ChAT; CHOACTase; Choline acetylase; choline acetyltransferase; CMS1A; CMS1A2; EC 2.3.1.6; OTTHUMP00000019583; OTTHUMP00000019584; CLAT_HUMAN. |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) Alzheimer's |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, Rat, (predicted: Dog, Pig, ) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:200-800 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 82kDa |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ChAT:101-200/748 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010]. Function: Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. DISEASE: Defects in CHAT are the cause of congenital myasthenic syndrome with episodic apnea (CMSEA) [MIM:254210]; formerly known as familial infantile myasthenia gravis 2 (FIMG2). CMSEA is an autosomal recessive congenital myasthenic syndrome. Patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. Similarity: Belongs to the carnitine/choline acetyltransferase family. SWISS: P28329 Gene ID: 1103 Database links: Entrez Gene: 1103 Human Entrez Gene: 12647 Mouse Omim: 118490 Human SwissProt: P28329 Human SwissProt: Q03059 Mouse Unigene: 302002 Human Unigene: 442817 Mouse Unigene: 45116 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 膽堿乙酰轉(zhuǎn)移酶是一種在神經(jīng)元胞體內(nèi)合成的酶。當(dāng)該轉(zhuǎn)移酶被合成以后，通過軸質(zhì)流動(dòng)方式轉(zhuǎn)移到神經(jīng)軸突末端。其功能是將乙酰輔酶A轉(zhuǎn)移到膽堿上，導(dǎo)致神經(jīng)遞質(zhì)乙酰膽堿的形成。膽堿能系統(tǒng)參與多種神經(jīng)功能。一些膽堿能神經(jīng)元的改變能導(dǎo)致阿爾茨海默病的發(fā)生。 膽堿乙酰轉(zhuǎn)移酶通常被用來(lái)標(biāo)記神經(jīng)元。 |
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