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凋亡抑制因子IASPP抗體

產(chǎn)品貨號(hào)：

BN41524R
中文名稱(chēng)：

凋亡抑制因子IASPP抗體
英文名稱(chēng)：

Rabbit anti-IASPP Polyclonal antibody
品牌：

Biorigin

貨號(hào)

產(chǎn)品規(guī)格

售價(jià)

備注
BN41524R-50ul

50ul

￥1486.00

交叉反應(yīng)：Human,Rat(predicted:Mouse,Dog,Cow,Sheep,GuineaPig) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
BN41524R-100ul

100ul

￥2360.00

交叉反應(yīng)：Human,Rat(predicted:Mouse,Dog,Cow,Sheep,GuineaPig) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
BN41524R-200ul

200ul

￥3490.00

交叉反應(yīng)：Human,Rat(predicted:Mouse,Dog,Cow,Sheep,GuineaPig) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱(chēng)	IASPP
中文名稱(chēng)	凋亡抑制因子IASPP抗體
別名	IASPP; inhibitor of apoptosis stimulating protein of p53; Inhibitor of ASPP protein; NFkB interacting protein 1; NKIP1; PPP1R13B-like protein; PPP1R13L; Protein iASPP; protein phosphatase 1 regulatory (inhibitor) subunit 13 like; RAI; RelA-associated inhibitor; IASPP_HUMAN; RelA-associated inhibitor; Inhibitor of ASPP protein; NFkB-interacting protein 1.
研究領(lǐng)域	腫瘤免疫學(xué) 染色質(zhì)和核信號(hào) 信號(hào)轉(zhuǎn)導(dǎo) 表觀(guān)遺傳學(xué)
抗體來(lái)源	Rabbit
克隆類(lèi)型	Polyclonal
交叉反應(yīng)	Human, Rat, (predicted: Mouse, Dog, Cow, Sheep, Guinea Pig, )
產(chǎn)品應(yīng)用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	89kDa
細(xì)胞定位	細(xì)胞核細(xì)胞漿細(xì)胞外基質(zhì)
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human IASPP:15-100/828
亞型	IgG
純化方法	affinity purified by Protein A
儲(chǔ) 存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	iASPP(inhibitor of apoptosis stimulating protein of p53)regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. Belongs to the ASPP family. Function: Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. Subunit: Interacts with RELA NF-kappa-B subunit and with SP1 via its C-terminus part. Interacts with p53/TP53, TP63 and TP73. Subcellular Location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic but also nuclear. Tissue Specificity: Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. Similarity: Belongs to the ASPP family. Contains 2 ANK repeats. Contains 1 SH3 domain. SWISS: Q8WUF5 Gene ID: 10848 Database links: Entrez Gene: 10848 Human Entrez Gene: 333654 Mouse Omim: 607463 Human SwissProt: Q8WUF5 Human SwissProt: Q3TCU2 Mouse SwissProt: Q5I1X5 Mouse Unigene: 466937 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. IASPP(inhibitory member of the ASPP family) 是新近發(fā)現(xiàn)的高度保守的p53相關(guān)基因, 是細(xì)胞凋亡ASPP家族的另一個(gè)成員。 iASPP能夠抑制ASPP1，2的促凋亡作用，其蛋白產(chǎn)物定位于細(xì)胞核內(nèi),具有結(jié)合NF-κB p65亞基和p53功能,進(jìn)而抑制NF-κB的轉(zhuǎn)錄調(diào)節(jié)和p53對(duì)凋亡的調(diào)節(jié)功能。研究者發(fā)現(xiàn)iASPP蛋白，能夠干擾p53基因發(fā)揮正常的促使細(xì)胞死亡的作用。這就意味著iASPP在正常細(xì)胞轉(zhuǎn)化為癌癥細(xì)胞方面起著重要的促進(jìn)作用，即iASPP具有促進(jìn)癌變的功能。表達(dá)位置：細(xì)胞漿，部分細(xì)胞核。 inhibitor of ASPP